Viral vaccines promote endoplasmic reticulum stress-induced unfolding protein response in teleost erythrocytes.

ABSTRACT: Most available evidence points to a proviral role for endoplasmic reticulum (ER) stress, as many viruses exploit it to promote viral replication. In contrast, few studies have linked ER stress to the antiviral immune response, and even fewer to the vaccine-induced immune response. In this work, we demonstrated that ER stress is a key molecular link in the immune response of teleost erythrocytes or red blood cells (RBCs) under vaccine stimulation. Moreover, the unfolded protein response (UPR^ER) triggered by ER stress may work together with autophagy and related cellular mechanisms as part of a coordinated immune response in RBCs. We unveiled biochemical changes in the lipid-protein profile of vaccine-treated RBCs by synchrotron radiation-based Fourier transform infrared microspec

SUBMITTER: Salvador-Mira M 

PROVIDER: S-EPMC12162347 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature