Histone demethylase JMJD2D emerges as a novel prognostic biomarker and exhibits correlation with immune infiltration in lung adenocarcinoma.

ABSTRACT:

Background

Lysine demethylase 4D (KDM4D or JMJD2D) plays a significant role in tumorigenesis, development, and poor clinical outcomes. However, its roles in lung adenocarcinoma (LUAD) remains unclear. This study aimed to identify the role and molecular mechanisms of JMJD2D in LUAD.

Methods

The study investigated the correlation of JMJD2D with tumor development, immune cell infiltration, response to antitumor therapy, tumor mutation burden and prognostic values.

Results

JMJD2D had high expression in LUAD. High-JMJD2D expression was associated with poor survival outcomes and the T stage of LUAD patients. Furthermore, high-JMJD2D expression was linked to the decreased immune-related processes, associated with the increased Tregs and CD40 expression. Additionally, high-JM

SUBMITTER: Liu B 

PROVIDER: S-EPMC12162437 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature