Interferon-β and interleukin-6 exert opposing effects on Foxp3 acetylation to control regulatory T cell induction.

ABSTRACT: Cytokines are key soluble signaling molecules that regulate immune responses. With the advent of therapies that selectively target cytokines and cytokine receptors, understanding the molecular mechanisms underpinning how immune cells integrate multiple cytokine signals has become a critical challenge in immunology. However, the pleiotropic nature of cytokines makes it difficult to decipher their precise contributions in various contexts. Here, we used an integrated experimental and computational approach to investigate the combined effect and interplay between the pro-inflammatory cytokine interleukin-6 (IL-6) and interferon-beta (IFNβ), also a pro-inflammatory cytokine with potent antiviral properties, in modulating regulatory T cell (Treg) induction. Our studies reveal that, in contrast

SUBMITTER: Ningoo M 

PROVIDER: S-EPMC12162494 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature