Preexisting statin therapy is not associated with reduced acute kidney injury following cardiac surgery: a retrospective analysis.

ABSTRACT:

Background

Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most prevalent forms of acute kidney injury (AKI) encountered in clinical practice, and its occurrence is significantly correlated with increased mortality and poor prognosis in patients. Although existing studies suggest that statins may influence the development of CSA-AKI through pleiotropic mechanisms, the findings from available studies and meta-analyses remain inconsistent. Therefore, the relationship between preexisting statin use and the risk of CSA-AKI development requires further investigation.

Methods

This study employed a retrospective cohort analysis based on the MIMIC-IV database. Patients undergoing ascending aortic surgery, coronary artery bypass grafting (CABG), or heart valve

SUBMITTER: Wang J 

PROVIDER: S-EPMC12162650 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature