From genomics to treatment: overcoming pan-drug-resistant <i>Klebsiella pneumoniae</i> in clinical settings.

ABSTRACT:

Introduction

The spread pan-drug resistant pathogens pose a critical challenge to current therapies, resulting in high mortality and necessitating alternative approaches.

Methods

We report pan-drug resistant Klebsiella pneumoniae isolates from five patients in a single hospital, including resistance to cefiderocol and cefepime-zidebactam in one isolate.

Results

Whole-genome sequencing identified blaNDM-5 and blaCTX-M-15 genes in all isolates, explaining carbapenemase and extended-spectrum β- lactamase phenotypes, with blaKPC-2 in one isolate. A novel sulfhydryl variable β-lactamase (SHV) variant, blaSHV-231, was present in all isolates under a strong promoter. Two isolates exhibited a non-synonymous mutation in fstI encoding PBP3, the primary target of aztreonam in Gr

SUBMITTER: Pasteran F 

PROVIDER: S-EPMC12162686 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature