Radiomic Analysis of Striatal [¹⁸F]FDOPA PET Imaging in Patients with Psychosis for the Identification of Antipsychotic Response.

ABSTRACT:

Purpose

Schizophrenia (SCZ) is a severe psychiatric disorder marked by abnormal dopamine synthesis, measurable through [¹⁸F]FDOPA PET imaging. This imaging technique has been proposed as a biomarker for treatment stratification in SCZ, where one-third of patients respond poorly to standard antipsychotics. This study explores the use of radiomics on [¹⁸F]FDOPA PET data to examine dopamine synthesis in SCZ and predict antipsychotic response.

Methods

We analysed 273 [¹⁸F]FDOPA PET scans from healthy controls (n = 138) and SCZ patients (n = 135) from multiple cohorts, including first-episode psychosis cases. Radiomic features from striatal regions were extracted using the MIRP Python package. Reproducibility was assessed with test-retest scans, s

SUBMITTER: Schiulaz A 

PROVIDER: S-EPMC12162767 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature