Immune Response to Bioluminescence Imaging Reporters in Murine Tumor Models.

ABSTRACT:

Purpose

Imaging reporters have been widely employed in cancer research to monitor real-time tumor burden and metastatic spread. These tools offer a valuable approach for non-invasive imaging of tumor dynamics over time. With the established understanding that tumor immunology plays a critical role in cancer progression, it is essential to ensure that the chosen imaging reporters used to study tumor-immune interactions do not inadvertently elicit an immune response. This study aimed to investigate the immune response to bioluminescence reporters used for in vivo tracking of tumor cells in immunocompetent murine models.

Procedures

The in vitro and in vivo growth effects of two stably expressed bioluminescence reporter genes, a red-shifted firefly luciferase and a click beetle

SUBMITTER: Basnet A 

PROVIDER: S-EPMC12162783 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature