Femoral bone growth predictions based on personalized multi-scale simulations: validation and sensitivity analysis of a mechanobiological model.

ABSTRACT: Musculoskeletal function is pivotal to long-term health. However, various patient groups develop torsional deformities, leading to clinical, functional problems. Understanding the interplay between movement pattern, bone loading and growth is crucial for improving the functional mobility of these patients and preserving long-term health. Multi-scale simulations in combination with a mechanobiological bone growth model have been used to estimate bone loads and predict femoral growth trends based on cross-sectional data. The lack of longitudinal data in the previous studies hindered refinements of the mechanobiological model and validation of subject-specific growth predictions, thereby limiting clinical applications. This study aimed to validate the growth predictions using magnetic resonan

SUBMITTER: Koller W 

PROVIDER: S-EPMC12162800 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature