Transcriptomic analysis of mammary gland tissues in lactating and non-lactating dairy goats reveals miRNA-mediated regulation of lactation, involution, and remodeling.

ABSTRACT:

Background

Dynamic changes in the mammary gland during lactation and the dry period involve proliferation, secretion, apoptosis, and remodeling of mammary epithelial cells. MicroRNAs (miRNAs) are recognized as critical regulators of mammary gland development and lactation. However, their expression patterns and regulatory mechanisms at different lactation stages-particularly during mammary involution and remodeling-remain poorly understood in dairy goats.

Methods

In this study, high-throughput sequencing was employed to analyze miRNA expression profiles in goat mammary tissues at five key stages: late gestation (LG), early lactation (EL), peak lactation (PL), late lactation (LL), and the dry period (DP). Differential expression analysis, miRNA clustering, Gene Ontology (GO)

SUBMITTER: Peng Y 

PROVIDER: S-EPMC12162918 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature