Transcriptomic and metabonomic profiling unveils the mechanism of Tartary buckwheat and kiwi co-fermentation products in hyperlipidemia treatment.

ABSTRACT:

Introduction

Tartary buckwheat (Fagopyrum tataricum, TB), a flavonoid-rich plant limited by anti-nutritional metabolites.

Methods

TB was co-fermented with kiwi juice (TB-KW) through alcohol fermentation to improve flavonoid extraction and utilization. The flavonoid profile of TB-KW was analyzed through untargeted metabolomics. The anti-hyperlipidemic effects of TB-KW were assessed in zebrafish maintained on a high-fat diet through transcriptomics and metabolomics.

Results

Untargeted metabolomic analysis showed that flavonoids originating from TB, including quercetin, luteolin, quercitrin, rutin, and kaempferide, were significantly enriched in TB-KW. The data further showed that TB-KW significantly reduced lipid accumulation in zebrafish. Metabolomic profiling r

SUBMITTER: Guohui N 

PROVIDER: S-EPMC12162925 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature