Steamed panax notoginseng mitigates CA-MRSA USA300-induced necroptosis in human neutrophils.

ABSTRACT:

Background

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) disrupts innate immunity by inducing necroptosis in polymorphonuclear neutrophils (PMNs), a process linked to excessive inflammation and tissue damage. CA-MRSA releases virulence factors that enhance its pathogenicity by disrupting the host's innate immune response, particularly impairing the phagocytic function of PMNs. Steamed Panax notoginseng (S-PN), a traditional Chinese medicine (TCM), has demonstrated immune-regulatory and anti-inflammatory properties, showing promising therapeutic effects in alleviating the severe inflammatory responses induced by pathogenic microbial infections.

Objective

This study aims to investigate the pharmacological effects and mechanisms of S-PN allev

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12163054 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature