Genomics yields biological and phenotypic insights into bipolar disorder.

ABSTRACT: Bipolar disorder is a leading contributor to the global burden of disease¹. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown². We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.8 million controls), combining clinical, community and self-reported samples. We identified 298 genome-wide significant loci in the multi-ancestry meta-analysis, a fourfold increase over previous findings³, and identified an ancestry-specific association in the East Asian cohort. Integrating results from fine-mapping and other variant-to-gene mapping approaches identified 36 credible genes in the aetiology of bipolar disorder. Genes priori

SUBMITTER: O'Connell KS 

PROVIDER: S-EPMC12163093 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature