Validation of a Chemotherapy Toxicity Prediction Model in Older Adults With Cancer in Taiwan.

ABSTRACT: IntroductionThe Cancer and Aging Research Group (CARG) model predicts chemotherapy-related toxicities in older patients; however, its applicability has not been validated in Taiwanese patients. This study aims to validate the CARG model in older Taiwanese patients with solid tumors.MethodsPatients (N = 258) aged ≥65 years with solid tumors from a single medical center, slated for first-line chemotherapy, were recruited between 2018 and 2021, with follow-up until December 31, 2022. Patients were categorized into low- (N = 85), medium- (N = 117), and high- (N = 56) risk based on CARG. Validation of CARG involved receiver operating characteristic (ROC) curves. Individual CARG variables were analyzed using univariate analysis for their impact on toxicities and survival.ResultsToxicities of gra

SUBMITTER: Chang CY 

PROVIDER: S-EPMC12163255 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature