Blood-brain barrier permeability in relation to disease severity and timing of multiple sclerosis diagnosis in optic neuritis.

ABSTRACT:

Background

Dynamic contrast-enhanced magnetic resonance imaging is a promising biomarker allowing for in vivo quantification of blood-brain barrier permeability.

Objectives

To explore the relationship between blood-brain barrier permeability, optic neuritis disease severity, and multiple sclerosis conversion in optic neuritis.

Methods

Gjedde-Patlak models from dynamic contrast-enhanced magnetic resonance imaging were used to estimate blood-brain barrier permeability (K_i ) in 78 optic neuritis patients. The 2017 McDonald criteria were used to diagnose multiple sclerosis with a minimum follow-up time of 2 years.

Results

Normal-appearing white matter K_i correlated with the number of magnetic resonance imaging criteria for dissem

SUBMITTER: Passali M 

PROVIDER: S-EPMC12163281 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature