Immunogenomic characteristics and prognostic implications of terminally exhausted CD8⁺ T cells in colorectal cancers.

ABSTRACT:

Introduction

T-cell exhaustion is a major mechanism of immune evasion. Recently, the therapeutic and prognostic implications of progenitor exhausted T cells (Tpex) and terminally exhausted T cells (Ttex) have been explored in various cancer types. This study explored the immunogenomic characteristics and prognostic implications of Tpex and Ttex in colorectal cancers (CRCs).

Methods

We performed multiplex immunofluorescence (mIF) using antibodies against CK, CD3, CD8, TCF1, and FOXP3 to assess diverse subsets of tumor-infiltrating lymphocytes (TILs) in 517 patients with stage III or high-risk stage II CRCs. We compared the infiltration level of these TIL subsets with the genetic profiles of CRCs, including microsatellite instability (MSI), tumor mutational burden (TMB), and m

SUBMITTER: Lee JA 

PROVIDER: S-EPMC12163321 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature