Comparison of Viral Aerosol Shedding by Mild and Moderately Symptomatic Community-Acquired and Nasally Inoculated Influenza A(H3) Infection.

ABSTRACT:

Background

Nasally inoculated influenza cases reported milder symptoms and shed lower viral RNA load in exhaled breath aerosols (EBA) than people with classic influenza-like illness in a previous study. Whether nasally inoculated influenza is representative of mild natural influenza infection is unknown. We extend previous analyses to include a broader range of community-acquired cases.

Methods

We previously studied (A) volunteers intranasally inoculated with a dose of 5.5 log₁₀TCID₅₀ of influenza A/Wisconsin/67/2005 (H3N2) and (B) cases with classic influenza-like illness including fever recruited in 2013. We now add (C) cases from a 2017-2019 surveillance cohort of college dormitory residents and their contacts and (D) cases from a university health c

SUBMITTER: Lai J 

PROVIDER: S-EPMC12163343 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature