Parkin mediates the mitochondrial dysfunction through mRpL18.

ABSTRACT: Loss of function of parkin leads to mitochondrial dysfunction, which is closely related to Parkinson's disease. However, the in vivo mechanism is far from clear. One dogma is that impaired Parkin causes dysfunction of mitophagy mediated by Pink1-Parkin axis. The other is that impaired Parkin causes Mfn accumulation which leads to mitochondrial dysfunction. Surprisingly, in Drosophila muscles, the first dogma is not applicable; for the second dogma, our study suggests that Parkin mediates mitochondrial dysfunction through the synergy of both Marf and mitochondrial protein mRpL18 got from our genome-wide screen, whose RNAi rescues parkin RNAi phenotype. Mechanistically, we found that impaired Parkin upregulated both transcription and protein levels of mRpL18 dependent on its E3 ligase activi

SUBMITTER: Ti X 

PROVIDER: S-EPMC12163413 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature