Circular RNA hsa_circ_103089 modulates metabolic glycolysis and influences migration, invasion, and cisplatin sensitivity in non-small cell lung cancer cells via the miR-876-5p/EGFR axis.

ABSTRACT: Lung cancer, particularly non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related mortality worldwide, driven by complex molecular mechanisms including metabolic reprogramming and chemoresistance. Circular RNAs (circRNAs) have emerged as key regulators in cancer progression, yet their specific roles in NSCLC are underexplored. This study identified hsa_circ_103089 as a novel circRNA upregulated in NSCLC tissues and cell lines through circRNA profiling using the Gene Expression Omnibus (GEO) database. We aimed to investigate its functional roles and molecular mechanisms in NSCLC progression and cisplatin (DDP) sensitivity. Using A549 and HCC827 cell lines, we assessed the effects of hsa_circ_103089 silencing on proliferation, migration, invasion, glycolysis, and DDP re

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12163446 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature