Metabolomic Changes in Major Depressive Disorder Adolescent Females with or without Suicide Attempts.

ABSTRACT:

Background

The incidence of Major Depressive Disorder (MDD) is high among adolescent females, and MDD is often accompanied by suicide attempts (SAs), which have a serious negative impact on health. However, changes in lipids, thyroid hormone, and brain metabolism among female adolescents with MDD and the relationships between these three markers and MDD with SA have yet to be elucidated.

Methods

This study enrolled 71 MDD patients with SA (MDD+SA), 66 MDD patients without SA (MDD-SA), and 47 healthy controls (HCs). We analysed the lipid and thyroid hormone levels and magnetic resonance spectroscopy results of the subjects.

Results

Low levels of social support, high levels of life stress, and high levels of suicidal ideation (SI) were risk factors for SA. In MDD patien

SUBMITTER: Deng WX 

PROVIDER: S-EPMC12163494 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature