Small Extracellular Vesicles Derived From Damaged Muscle Aggravate Kidney Injury Progression.

ABSTRACT:

Background

Muscle atrophy is commonly associated with kidney dysfunction in patients with renal disease. However, the effects of skeletal muscle loss per se on kidney function have not been fully elucidated. Here, we examined muscle-kidney crosstalk by evaluating the role of muscle-derived small extracellular vesicles (EVs) on the progression of kidney injury.

Methods

A denervation-induced muscle loss model was established, and kidney inflammation and fibrosis were evaluated in unilateral ureteral obstruction (UUO)-induced kidney injury and adenine diet-induced chronic kidney disease models. Changes in small EV markers (CD9, CD63, CD81 and Alix) were measured. GW4869, an inhibitor of EV biogenesis and release, was used to confirm the role of denervated muscle-derived small E

SUBMITTER: Jiang S 

PROVIDER: S-EPMC12163521 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature