Acute effects of intranasal esketamine application on thalamic structures in healthy individuals.

ABSTRACT:

Background

The N-methyl-D-aspartate receptor antagonist ketamine has found broad application in the field of psychiatry. Due to its rapid antidepressant and anti-suicidal properties, it is used as a treatment for major depressive disorder. Furthermore, ketamine evokes dissociative and psychotropic states, which allows the modeling of schizophrenic symptoms. The thalamus, a main target for ketamine's actions, consists of different nuclei responsible for sensory gating, attention, and consciousness. Thus, we here examine the effects of intranasally applied ketamine on thalamic structures in healthy individuals in a cross-over placebo-controlled study.

Methods

Twenty-six subjects (14 female, mean age ± SD = 24.3 ± 3 years) underwent two magnetic resonance imaging scans on a 3T

SUBMITTER: Spurny-Dworak B 

PROVIDER: S-EPMC12163588 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature