A multidomain trial for cognition in women with cardiovascular disease.

ABSTRACT:

Introduction

We evaluated the independent and combined efficacies of MindMoves (24-week physical activity and cognitive training) on cognition and serum neurotrophic biomarkers in older women with cardiovascular disease (CVD).

Methods

This 2 × 2 factorial design randomized controlled trial (NCT04556305) tested efficacies of Mind (cognitive training) and Move (lifestyle physical activity) on change in cognition (global composite derived from three domains) and four serum biomarkers at baseline, 24, 48, and 72 weeks post-baseline in older women with CVD without cognitive impairment.

Results

Of 253 participants randomized (mean age = 72.8; 57% non-Hispanic White), 87% completed the trial, though health-behavior adherence was low (Mind 45%, Move 33%). Interventions were n

SUBMITTER: Halloway S 

PROVIDER: S-EPMC12163647 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature