<i>C</i>‑methylated Flavanones with Antitrypanosomal Activity Isolated of Geopropolis from <i>Melipona mondury</i>.

ABSTRACT: Geopropolis is a natural antibiotic produced by stingless bees, supplemented with earth and clay. Bee products are a promising source of natural bioactive compounds with potential for the development of new drugs for neglected tropical diseases, such as Chagas disease. This study analyzed extracts of Melipona mondury geopropolis from the Bosque da Barra da Tijuca (RJ, Brazil) and evaluated their activity against Trypanosoma cruzi. The extracts were obtained using commercial grain alcohol 96° GL and fractionated with hexane and dichloromethane. The antichagasic activity was determined, with IC₅₀ values ranging from 4.54 to 53.02 μg/mL. Phytochemical investigation of the dichloromethane fraction resulted in the isolation of two C-methylated flavanones, (2S<

SUBMITTER: Dos Santos RF 

PROVIDER: S-EPMC12163691 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature