Zinc Complexes of Cationic Ammonium Phenyl and Methylpyridinium Porphyrins Display Synergistic Anti-HIV‑1 and Broad-Spectrum Antibacterial Activity.

ABSTRACT: This study presents a pioneering series of cationic porphyrins with promising synergistic antimicrobial and anti-HIV properties, particularly effective against drug-resistant strains. The synthesized porphyrins, including P ₃ AmM, PAm ₃ M, and c-P ₂ Am ₂ M, as well as their zinc-(II) complexes (P ₃ AmZM, PAm ₃ ZM, and c-P ₂ Am ₂ ZM), were developed through strategic methylation of primary amino groups in precursor porphyrins, addressing steric challenges associated with repetitive amine alkylation. Under photodynamic therapy (PDT) conditions, these com

SUBMITTER: Sharma D 

PROVIDER: S-EPMC12163793 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature