Isoniazid-Modified Silica for Hydrophilic Interaction Chromatography and as an Adsorbent for Dye Removal in Wastewater Samples.

ABSTRACT: The new isoniazid-derived material was synthesized with a surface-immobilizable functional group by a reaction between isoniazid and succinyl anhydride and grafted onto silica surfaces. The material was designed so that multiple functional groups could interact with the guest molecules. Initially, the silica surface was modified with 3-amipropyltrimethoxysilane. Succinyl isoniazid (SID) was synthesized and then immobilized to 3-aminopropylsilica by an amide coupling reaction to obtain Sil-SID. The ATR-FTIR and ¹H NMR were used to characterize the SID before immobilization. After grafting, Sil-SID was confirmed by elemental analysis, ATR-FTIR, scanning electron microscopy, and thermogravimetric analysis (TGA). The same material was finally used as a stationary phase in hydrophili

SUBMITTER: Mallik AK 

PROVIDER: S-EPMC12163811 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature