Role of long non-coding RNAs and circular RNAs in kawasaki disease: a systematic review.

ABSTRACT:

Objective

Previous research has identified the significant roles of non-coding RNAs (ncRNAs) in Kawasaki disease (KD). This systematic review aims to elucidate the involvement and significance of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in the pathogenesis and progression of KD.

Study design

A systematic search was conducted across four databases (PubMed, Embase, Scopus, and Web of Science) up to June 19, 2023, without year restrictions. The risk of bias was assessed using the Newcastle-Ottawa Scale.

Results

This review included 9 studies encompassing a total of 1894 individuals diagnosed with KD. Seven lncRNAs-Slco4a1, SOCS2-AS1, SRA, HCG22, MHRT, XLOC_006277, and HSD11B1-AS1-were found to be associated with KD, including polymorphisms such as lncR

SUBMITTER: Amirsardari Z 

PROVIDER: S-EPMC12164146 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature