Cryo-EM Structures of Apo and DDT-Bound P-Glycoprotein in Yellowfin Tuna.

ABSTRACT: Persistent pollutants in the ocean impact the safety of seafood. Many emerging and legacy persistent organic pollutants (POPs) have been disposed into the world's oceans, exemplified by the recent discovery of large amounts of the halogenated pesticide dichlorodiphenyltrichloroethane (DDT) waste in the waters of Southern California. The biological mechanisms governing persistence and trophic transfer of marine pollutants into seafood species remain incompletely understood. Xenobiotic transporters, such as P-glycoprotein (P-gp), are present in all organisms and prevent the accumulation of toxic chemicals. Our previous work has demonstrated that halogenated marine pollutants can act as inhibitors of human and murine P-gp transporters by interacting with their binding site and impeding transp

SUBMITTER: Young MA 

PROVIDER: S-EPMC12164267 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature