Molecular characterisation of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis.

ABSTRACT:

Background and aims

Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We aimed to identify unique molecular traits characterising NASH-HCC compared to other HCC aetiologies.

Methods

We collected 80 NASH-HCC and 125 NASH samples from 5 institutions. Expression array (n = 53 NASH-HCC; n = 74 NASH) and whole exome sequencing (n = 52 NASH-HCC) data were compared to HCCs of other aetiologies (n = 184). Three NASH-HCC mouse models were analysed by RNA-seq/expression-array (n = 20). Activin A receptor type 2A (ACVR2A) was silenced in HCC cells and proliferation assessed by colorimetric and colony formation assays.

Results

Mutational profiling of NASH-HCC tumours revealed TERT p

SUBMITTER: Pinyol R 

PROVIDER: S-EPMC12164395 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature