Outer Membrane Vesicles from <i>Caulobacter crescentus</i>: A Platform for Recombinant Antigen Presentation.

ABSTRACT: Bacterial outer membrane vesicles (OMVs) are an emerging and attractive technology for the generation of vaccines. Their properties as natural adjuvants, size, acellularity, and comparative cost of production favor their use as vaccines. Two major caveats for the use of OMVs as vaccines are their biological safety, since OMVs can induce a severe and even fatal inflammatory response and that they are naturally produced in low amounts. In this study, we show that a strategy to induce the production of OMVs applied to the nonpathogenic bacterium Caulobacter crescentus results in a strain with good OMV yields. In comparison with the OMVs derived from Escherichia coli K-12, the OMVs from C. crescentus induce a lower inflammatory response in an in vivo murine model of

SUBMITTER: Ginez LD 

PROVIDER: S-EPMC12164514 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature