GBA1 rs3115534 Is Associated with REM Sleep Behavior Disorder in Parkinson's Disease in Nigerians.

ABSTRACT:

Background

Rapid eye movement (REM) sleep behavior disorder (RBD) is an early feature of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Damaging coding variants in Glucocerebrosidase (GBA1) are a genetic risk factor for RBD. Recently, a population-specific non-coding risk variant (rs3115534) was found to be associated with PD risk and earlier onset in individuals of African ancestry.

Objectives

We aimed to investigate whether the GBA1 rs3115534 PD risk variant is associated with RBD in persons with PD.

Methods

We studied 709 persons with PD and 776 neurologically healthy controls from Nigeria. All DNA samples were genotyped and imputed, and the GBA1 rs3115534 risk variant was extracted. The RBD screening questionnaire (RBDSQ) was used to assess symptoms

SUBMITTER: Ojo OO 

PROVIDER: S-EPMC12164542 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature