IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8⁺ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development.

ABSTRACT: Abdominal aortic aneurysm (AAA) is the most common true aneurysm worldwide, and recent studies suggest that dendritic cells (DCs) play a key role in its development, though the specific subtypes and underlying mechanisms remain unclear. In this study, the role of interferon regulatory factor 8 (IRF8) in AAA is investigated by focusing on its effect on the differentiation of DC precursors into conventional type 1 dendritic cells (cDC1s). It is found significant infiltration of HLA-DR⁺ IRF8⁺ cells in human AAA tissue samples. In mice, DC-specific overexpression of Irf8 exacerbates aneurysm expansion following periadventitial elastase application, while DC-specific Irf8 deletion attenuates AAA development. Batf3^-/- mice, which lack cDC1s, exhibit AAA character

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC12165085 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature