Autonomous Self-Evolving Research on Biomedical Data: The DREAM Paradigm.

ABSTRACT: In contemporary biomedical research, the efficiency of data-driven methodologies is constrained by large data volumes, the complexity of tool selection, and limited human resources. To address these challenges, a Data-dRiven self-Evolving Autonomous systeM (DREAM) is developed as the first fully autonomous biomedical research system capable of independently conducting scientific investigations without human intervention. DREAM autonomously formulates and evolves scientific questions, configures computational environments, and performs result evaluation and validation. Unlike existing semi-autonomous systems, DREAM operates without manual intervention and is validated in real-world biomedical scenarios. It exceeds the average performance of top scientists in question generation, achieves a

SUBMITTER: Deng L 

PROVIDER: S-EPMC12165099 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature