WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency.

ABSTRACT:

Purpose

Dry eye disease is characterized by abnormal tear film composition and inflammation. Disruptions in the presence or secretory function of acinar cells can result in dry eye, leading to discomfort, damage, and vision loss. Although tear replacement and anti-inflammatory treatments have been investigated thoroughly, a method to induce epithelial restoration is lacking. Here, we asked whether WNT signaling activation via an antibody-based WNT mimetic platform might activate lacrimal gland acinar cells and restore tear secretion.

Methods

Primary murine lacrimal gland cells were used to establish three-dimensional acinar cell organoids. Dry eye disease was modeled in mice using a lacrimal gland excretory duct ligation. Transcriptional and cellular changes were investigate

SUBMITTER: Nguyen H 

PROVIDER: S-EPMC12165264 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature