Comprehensive genomic analysis of type VI secretion system diversity and associated proteins in <i>Serratia</i>.

ABSTRACT: The type VI secretion system (T6SS) is a contact-dependent contractile nanomachine widely distributed among Gram-negative bacteria, essential for interbacterial competition, host interactions and environmental adaptation. The T6SS encoded by Serratia is known to play roles in bacterial competition and contribute to niche adaptation. Yet, the diversity and distribution of T6SS loci and relevant proteins across different Serratia species remain underexplored. In this study, we conducted bioinformatic and comparative genomic analyses of the T6SS to expand our understanding of T6SS in Serratia and their distribution within the genus. A dataset comprising 2,337 Serratia genomes was analysed, identifying 4 distinct T6SS loci classified into 3 main types based on TssB

SUBMITTER: Jiang L 

PROVIDER: S-EPMC12165300 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature