Sentinel NOSE: Prospective feasibility study on sentinel lymph node biopsy in bulky nasal vestibule cancer.

ABSTRACT:

Objective

Patients with bulky squamous cell carcinoma of the nasal vestibule are at high risk of nodal relapse and have worse prognosis, despite modern neck imaging. More sensitive assessment of the neck may obviate elective treatment and ultimately reduce the risk of nodal relapse and improve outcome. The goal of this study was to evaluate the feasibility, safety and tolerability of sentinel lymph node biopsy (SLNB) in staging of bulky squamous cell nasal vestibule carcinoma (NVC).

Methods

Ten patients with cT1-T2N0 squamous cell NVC with diameter ≥1.5 cm, planned for curative brachytherapy, were prospectively included to undergo four peritumoral injections of ICG-[99mTc]Tc-nanocolloid. Subsequently, dynamic, static and SPECT/CT images were performed. The following day SLNB

SUBMITTER: Czerwinski MD 

PROVIDER: S-EPMC12165422 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature