Impact of predicted microbiota tryptophanase activity on Cryptosporidium parvum proliferation.

ABSTRACT: Protozoa in the genus Cryptosporidium infect intestinal epithelial cells. The profile of the fecal microbiota has been shown to impact the proliferation of Cryptosporidium parvum in a mouse model of cryptosporidiosis and a reverse effect of the parasite on the microbiota has also been described. The mechanisms underlying this interaction are unknown. The lack of effective drugs and vaccines is motivating the search for pro- or prebiotics capable of increasing resistance to parasite proliferation in the gastrointestinal tract. To understand if and how the intestinal microbiota could be harnessed for this purpose, we tested if C. parvum proliferation in the mouse responds to oral administration of Escherichia coli. This bacterium was chosen because of its reported importance in mediating col

SUBMITTER: Romualdo da Silva DR 

PROVIDER: S-EPMC12165429 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature