Differentially Expressed MicroRNAs in Testes of Dominant and Subordinate Nile Tilapia Males and Identification of Oni-miR-499 as Regulator of amh Gene Expression.

ABSTRACT:

Introduction

Gonadal development and reproduction are under the control of the endocrine system, which acts along the brain-pituitary-gonad (BPG) axis. Besides well-known regulators of the BPG axis, such as the gonadotropin-releasing hormone, follicle-stimulating hormone, and luteinizing hormone, the anti-Müllerian hormone (Amh) came into the focus of research on the BPG axis. Amh is expressed differently in the gonads of dominant and subordinate Nile tilapia (Oreochromis niloticus) males and could be involved in the regulation of the differently developed gonads. In addition, the regulatory networks and the control of gene expression depend on microRNAs (miRNAs), an often not considered epigenetic mechanism in hormonal research.

Methods

We used a long-term, stable social hi

SUBMITTER: Prause R 

PROVIDER: S-EPMC12165630 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature