Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis.

ABSTRACT: Owing to its extremely high prevalence and the distressing consequence of tooth loss, periodontitis has attracted substantial research attention. In light of these conditions, graphene-based biomaterials have emerged as a potentially promising approach for periodontal regeneration. This study focuses on the synthesis of polydopamine-coated reduced graphene oxide (RGO@PDA), designed to harness the anti-inflammatory properties of dopamine and the osteogenic potential of graphene oxide for synergistic periodontitis treatment. RGO@PDA was synthesized through a 12-h magnetic stirring process of graphene oxide and dopamine at room temperature. This water-dispersible and biocompatible compound demonstrated remarkable efficacy in enhancing osteogenic differentiation in rat bone mesenchymal stem ce

SUBMITTER: Jiang X 

PROVIDER: S-EPMC12165884 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature