MASP1 in stomach adenocarcinoma: linking diagnosis, prognosis, and tumor immunity.

ABSTRACT:

Background

This study explored the role of Mannose-Binding Lectin-Associated Serine Protease 1 (MASP1) in the diagnosis, prognosis, and immune landscape of stomach adenocarcinoma (STAD), with the aim of providing a molecular foundation for developing early, non-invasive diagnostic tools and advancing immunotherapeutic strategies.

Methods

We analyzed STAD messenger RNA (mRNA) data from The Cancer Genome Atlas (TCGA), immune-related gene data from the ImmPort database, and complement system-related genes from previous studies. Differentially expressed mRNAs (DEmRNAs) relevant to prognosis, immunity, and the complement system were identified using the "limma" and "survival" packages, alongside a Venn diagram. We confirmed MASP1 expression through analysis of external databases,

SUBMITTER: Xiao C 

PROVIDER: S-EPMC12165917 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature