Dynamics of mitochondrial DNA copy number regulation in relation to gastric cancer survival.

ABSTRACT:

Purpose

To investigate the causal effects of gene expression levels associated with mitochondrial DNA copy number (mtDNA-CN) on cancer survival outcomes.

Methods

We performed two-sample mendelian randomization (MR) analyses to evaluate the causal relationship between mtDNA-CN in peripheral blood and overall survival period of different cancer types. Additionally, colocalization analyses were performed to identify genes whose expression correlates with mtDNA-CN. Furthermore, we investigated how expression levels of these genes impact survival period in different cancers.

Results

Higher mtDNA-CN in peripheral blood is significantly associated with reduced survival period in gastric cancer (HR = 72.97, 95% CI 68.86 to 77.08, p = 0.046). Colocalization analysis identified

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12165923 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature