Biomarkers for pneumonia after major trauma: A systematic review and meta-analysis.

ABSTRACT:

Background

Major trauma is a significant global health issue. Pneumonia poses an additional risk for morbidity and mortality after major trauma yet identifying pneumonia remains challenging in clinical practice. This systematic review aims to evaluate blood-based biomarkers for pneumonia in major trauma patients.

Methods

The search was performed across four databases up to November 18th 2024, including primary studies investigating blood-based biomarkers associated with pneumonia in adults hospitalised after major trauma (PROSPERO CRD42024542059). Risk of bias was assessed using the ROBINS-E tool and meta-analysis was performed of pooled data.

Results

Among 20 included studies, with a total of 4316 participants, the pooled mean pneumonia rate was 32.7% (23.5%-43.4%).

SUBMITTER: Howroyd F 

PROVIDER: S-EPMC12165960 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature