Micronutrients, Vitamin D, and Inflammatory Biomarkers in COVID-19: A Systematic Review and Meta-analysis of Causal Inference Studies.

ABSTRACT:

Context

Experimental and observational studies suggest that circulating micronutrients, including vitamin D (VD), may increase COVID-19 risk and its associated outcomes. Mendelian randomization (MR) studies provide valuable insight into the causal relationship between an exposure and disease outcomes.

Objectives

The aim was to conduct a systematic review and meta-analysis of causal inference studies that apply MR approaches to assess the role of these micronutrients, particularly VD, in COVID-19 risk, infection severity, and related inflammatory markers.

Data sources

Searches (up to July 2023) were conducted in 4 databases.

Data extraction and analysis

The quality of the studies was evaluated based on the MR-STROBE guidelines. Random-effects meta-analyses were

SUBMITTER: Alcala-Santiago A 

PROVIDER: S-EPMC12166185 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature