Early steps of embryo implantation are regulated by exchange of extracellular vesicles between the embryo and the endometrium.

ABSTRACT: In early pregnancy, as the embryo arrives in the uterus, intensive communication between the embryo and uterus begins. Hundreds of molecules are known to be involved, but despite numerous findings, full understanding of the complexity of the embryo-maternal dialog remains elusive. Recently, extracellular vesicles, nanoparticles able to transfer functionally active cargo between cells, have emerged as important players in cell-cell communication, and as such, they have gained great attention over the past decade also in reproductive biology. Here, we use a domestic animal model (Sus scrofa) with an epitheliochorial, superficial type of placentation because of its advantage in studding uterine luminal fluid extracellular vesicles. We show that during early pregnancy, the uterine lumen is abu

SUBMITTER: Szuszkiewicz J 

PROVIDER: S-EPMC12166289 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature