Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria.

ABSTRACT:

Importance

Accurate and timely confirmation of death by neurologic criteria (DNC) is essential for clinical decision-making and organ-donation processes, yet currently available ancillary tests have suboptimal diagnostic performance or limited validation.

Objectives

To determine the diagnostic accuracy, interrater reliability, and safety of brain computed tomography (CT) perfusion and CT angiography as ancillary investigations for DNC.

Design, setting, and participants

Between April 25, 2017, and March 10, 2021, a prospective, multicenter, blinded diagnostic accuracy cohort study was conducted in 15 adult intensive care units across Canada. Consecutive, critically ill adults (aged ≥18 years) with a Glasgow Coma Scale score of 3 and no confounding factors who were at h

SUBMITTER: Chasse M 

PROVIDER: S-EPMC12166499 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature