Mendelian randomization study of micronutrients and development of CKD in a Korean population.

ABSTRACT:

Background

Although dietary intake is a key modifiable risk factor in the development of chronic kidney disease (CKD), the optimal consumption levels to prevent CKD and the intake levels that pose the least risk remain unclear. Building on the findings from our previous cohort study, this research aims to use genetic variants as instrumental variables to clarify the complex relationship between micronutrient status and the pathogenesis of CKD.

Methods

Of 5,078 participants with a baseline estimate glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m² and who were not diagnosed with CKD, we ascertained 708 new CKD cases over 12 year follow-up periods. Mendelian randomization analyses were conducted using genetic instrumental variables to examine the causal relation

SUBMITTER: Lee J 

PROVIDER: S-EPMC12166562 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature