Fatty acid metabolism of granulose cells and follicular fluid and their associations with embryo quality in normal-weight women with PCOS.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is the most common reproductive-endocrine disorder in women of reproductive age. The granulosa cell metabolism correlated with oocyte competence. However, the alteration of fatty acid in granulosa cell of PCOS patients is unclear. Besides, obesity per se is related to dysfunction of oocyte quality. Hence, this study was aimed to comprehensively investigate the fatty acid alteration of oocyte environment and their associations with embryo quality in normal weight women with PCOS.

Method

Two independent prospective cohorts included women with PCOS and age-BMI-matched controls that underwent IVF treatment were recruited. DIA-mass spectrometry-based proteomics analysis and absolute quantification of fatty acids were conducted in granul

SUBMITTER: Tian Y 

PROVIDER: S-EPMC12166564 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature