Astragaloside IV regulates FOXM1 deubiquitination to ameliorate trophoblast damage caused by high glucose.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is a common metabolic complication during pregnancy that poses significant risks to both the pregnant woman and her fetus. Astragaloside IV (Ast IV) belongs to the class of triterpenoid saponins and exhibits important physiological roles in various aspects, including antidiabetic, antioxidant, and antiviral effects. The main objective of this study is to investigate the effects of Ast IV on trophoblast damage caused by high glucose (HG) and its underlying mechanism of action.

Methods

Cell viability was determined by the CCK8 assay. The levels of oxidative stress in cells were determined by lactate dehydrogenase (LDH), malondialdehyde (MDA), and reactive oxygen species (ROS) kits. Ferroptosis in cells was assessed by the iron con

SUBMITTER: Li F 

PROVIDER: S-EPMC12166594 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature