Short-term pre-meal whey protein microgel supplementation reduces postprandial glycemia and appetite in adults with overweight: An open-label randomised controlled trial.

ABSTRACT:

Background

Premeal whey protein (WP) consumption may reduce postprandial glucose (PPG) levels and appetite. We assessed the effects of twice daily consumption of a low-dose non-gelling novel WP formulation (WP microgel [WPM]) on PPG, self-reported appetite, and ad-libitum food consumption.

Methods

This was a randomized, prospective, open-label, controlled, single-center crossover study, and adults with BMI 27-35 kg/m² were randomized to consume either 125 mL of 10 g WPM or control (water) 15 min before breakfast and lunch for four consecutive days. Three days were under free-living conditions, and the 4th day was at the clinic where breakfast (09:00 a.m.) was standardized (323 kcal, 7.0 g proteins), and lunch (12:00 p.m.) ad-libitum (pizza, 228.8 kcal/9.9 g protei

SUBMITTER: Neeland IJ 

PROVIDER: S-EPMC12166780 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature