Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron disease.

ABSTRACT:

Background

Motor neuron disease (MND) leads to progressive functional decline, making reliable measures of disease progression critical for patient care and clinical trials. Current clinical outcome measures lack the ability to continuously and objectively track functional decline in daily life of patients with MND. This study assessed and validated wrist-worn accelerometry outcome measures for continuous monitoring in MND, with the potential to refine clinical trial outcomes.

Methods

This longitudinal study included 95 patients with MND who wore an ActiGraph GT9X Link device on their non-dominant wrist for 8 days, with follow-up every 3-4 months. Accelerometer data were processed using ActiLife and GGIR. Joint models were used to simultaneously investigate the longitudinal

SUBMITTER: Holdom CJ 

PROVIDER: S-EPMC12166790 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature