Comparative analysis of duck Tembusu virus Cluster 1 and Cluster 2.1 in <i>Culex tritaeniorhynchus</i>: Insights into viral characteristics, infectivity, and innate immune response.

ABSTRACT: The disease caused by the duck Tembusu virus (DTMUV) is one of the most prevalent arthropod-borne viral diseases in poultry. DTMUV is classified into three distinct clusters based on significant genetic divergence: Cluster 1, Cluster 2 (subdivided into 2.1 and 2.2), and Cluster 3. The virulence of DTMUV in ducks is potentially associated with the virus genotype. The evaluation of different clusters of DTMUV is based predominantly on the characterization of infected duck hosts, and limited attention has been paid to understanding viral virulence toward the infected mosquito vectors. In this study, we explore the infectivity patterns of DTMUV Cluster 1 (DTMUV 1) and Cluster 2.1 (DTMUV 2.1) in the primary mosquito vector, Culex tritaeniorhynchus. Our objective was to explore the relati

SUBMITTER: Sri-In C 

PROVIDER: S-EPMC12166833 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature